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M9480034.TXT
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1994-08-09
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Document 0034
DOCN M9480034
TI Circannual variation in lymphocyte subsets, revisited.
DT 9410
AU Paglieroni TG; Holland PV; Sacramento Medical Foundation Center for
Blood Research,; California.
SO Transfusion. 1994 Jun;34(6):512-6. Unique Identifier : AIDSLINE
MED/94295067
AB BACKGROUND: Circadian and circannual variations in lymphocyte subsets,
especially CD8+ T-lymphocytes, have been reported. This study focuses on
CD4+ T-lymphocyte seasonal variation over a 6-year 8-month period. STUDY
DESIGN AND METHODS: Lymphocyte subsets were quantitated monthly for four
healthy individuals from 1986 through 1992 as part of a flow cytometry
quality-control program. RESULTS: In general, there were no significant
seasonal changes in the total number of white cells or in total
lymphocyte counts. The absolute numbers of CD4+ T-lymphocytes were
lowest in summer when the CD8+ T-lymphocytes were highest. Mean CD4+
T-lymphocyte counts were 846, 967, 618, and 695 per microL for Subjects
1 through 4, respectively, in winter and 432, 670, 355, and 766 per
microL, respectively, in summer. Two healthy subjects had CD4+
T-lymphocyte counts lower than 300 per microL on one or more occasions
during the study period. In three of the four subjects, the percentage
of B-lymphocytes in winter was almost double that in summer. In one of
the four subjects, no circannual rhythm was observed in these lymphocyte
subpopulations. CONCLUSION: The seasonal variation in CD4+ T-lymphocyte
counts demonstrated in three healthy individuals over almost 7 years is
again of interest in light of renewed consideration of using surrogate
tests, such as CD4+ T-lymphocyte counts, to screen for AIDS-like
diseases that may be in the blood supply.
DE Adult Antigens, CD8/ANALYSIS *Biological Clocks Comparative Study
Female Human Leukocyte Count *Lymphocyte Subsets Male Middle Age
Seasons T-Lymphocytes/IMMUNOLOGY T4 Lymphocytes JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).